The cap-translation inhibitor 4EGI-1 induces apoptosis in multiple myeloma through Noxa induction

BACKGROUND: Cancer cells are frequently addicted to deregulated oncogenic protein translation. The small molecule 4EG-I selectively inhibits the cap-dependent translation of mRNAs. As multiple myeloma is an incurable disease that requires new therapeutic approaches, we investigated whether targeting...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Descamps, G, Gomez-Bougie, P, Tamburini, J, Green, A, Bouscary, D, Maïga, S, Moreau, P, Le Gouill, S, Pellat-Deceunynck, C, Amiot, M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
Schlagworte:
Translational Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349175/
https://ncbi.nlm.nih.gov/pubmed/22510748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.139
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