Autocrine insulin-like growth factor 1 and stem cell factor but not interleukin 6 support self-renewal of human myeloma cells

In this study, we have identified the growth factors supporting myeloma self-renewal in eight myeloma cell lines. All cell lines able to form self-colonies displayed constitutive P-AKT and P-ERK1,2 but not P-STAT3 and did not express CD45, suggesting the presence of an insulin-like growth factor 1 (...

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Detalhes bibliográficos
Main Authors: Chiron, D, Maïga, S, Surget, S, Descamps, G, Gomez-Bougie, P, Traore, S, Robillard, N, Moreau, P, Le Gouill, S, Bataille, R, Amiot, M, Pellat-Deceunynck, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698536/
https://ncbi.nlm.nih.gov/pubmed/23749045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2013.18
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