REQUIREMENT OF ARGININOSUCCINATE LYASE FOR SYSTEMIC NITRIC OXIDE PRODUCTION

Nitric Oxide (NO) plays a critical role in diverse physiological and pathological processes. We show that a hypomorphic mouse model of argininosuccinate lyase (Asl) deficiency exhibits a distinct phenotype manifest by multi-organ dysfunction and NO deficiency. Loss of Asl leads to reduced NO synthes...

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Detalhes bibliográficos
Main Authors: Erez, Ayelet, Nagamani, Sandesh CS., Shchelochkov, Oleg A., Premkumar, Muralidhar H., Campeau, Philippe M., Chen, Yuqing, Garg, Harsha K., Li, Li, Mian, Asad, Bertin, Terry K., Black, Jennifer O., Zeng, Heng, Tang, Yaoping, Reddy, Anilkumar K., Summar, Marshall, O’Brien, William E., Harrison, David G., Mitch, William E., Marini, Juan C., Aschner, Judy L., Bryan, Nathan S., Lee, Brendan
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348956/
https://ncbi.nlm.nih.gov/pubmed/22081021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2544
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