REQUIREMENT OF ARGININOSUCCINATE LYASE FOR SYSTEMIC NITRIC OXIDE PRODUCTION

Nitric Oxide (NO) plays a critical role in diverse physiological and pathological processes. We show that a hypomorphic mouse model of argininosuccinate lyase (Asl) deficiency exhibits a distinct phenotype manifest by multi-organ dysfunction and NO deficiency. Loss of Asl leads to reduced NO synthes...

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Xehetasun bibliografikoak
Egile Nagusiak: Erez, Ayelet, Nagamani, Sandesh CS., Shchelochkov, Oleg A., Premkumar, Muralidhar H., Campeau, Philippe M., Chen, Yuqing, Garg, Harsha K., Li, Li, Mian, Asad, Bertin, Terry K., Black, Jennifer O., Zeng, Heng, Tang, Yaoping, Reddy, Anilkumar K., Summar, Marshall, O’Brien, William E., Harrison, David G., Mitch, William E., Marini, Juan C., Aschner, Judy L., Bryan, Nathan S., Lee, Brendan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348956/
https://ncbi.nlm.nih.gov/pubmed/22081021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2544
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