REQUIREMENT OF ARGININOSUCCINATE LYASE FOR SYSTEMIC NITRIC OXIDE PRODUCTION

Nitric Oxide (NO) plays a critical role in diverse physiological and pathological processes. We show that a hypomorphic mouse model of argininosuccinate lyase (Asl) deficiency exhibits a distinct phenotype manifest by multi-organ dysfunction and NO deficiency. Loss of Asl leads to reduced NO synthes...

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Main Authors: Erez, Ayelet, Nagamani, Sandesh CS., Shchelochkov, Oleg A., Premkumar, Muralidhar H., Campeau, Philippe M., Chen, Yuqing, Garg, Harsha K., Li, Li, Mian, Asad, Bertin, Terry K., Black, Jennifer O., Zeng, Heng, Tang, Yaoping, Reddy, Anilkumar K., Summar, Marshall, O’Brien, William E., Harrison, David G., Mitch, William E., Marini, Juan C., Aschner, Judy L., Bryan, Nathan S., Lee, Brendan
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348956/
https://ncbi.nlm.nih.gov/pubmed/22081021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2544
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