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The synthesis of branched-chain 3'-C-cyanomethyl-2',3'-dideoxy sugar nucleosides of adenine as potential inhibitors of the human immunodeficiency virus.

Condensation of the 3'-ketonucleoside 4 with diethyl cyanomethylphosphonate by a Wittig reaction afforded, after reduction of the unsaturated branched chain sugar nucleoside 5 with sodium borohydride, a mixture of 9-(2',5'-di-O-t-butyldimethylsilyl-3'-C-cyanomethyl-3'-deoxy-...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Halmos, T, Montserret, R, Antonakis, K
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 1989
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC334875/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2798123/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/17.19.7663
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