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Role of a Conserved Arginine Residue in Linkers between the Ketosynthase and Acyltransferase Domains of Multimodular Polyketide Synthases

The role of interdomain linkers in modular polyketide synthases is poorly understood. Analysis of the 6-deoxyerythronolide B synthase (DEBS) has yielded a model in which chain elongation is governed by interactions between the acyl carrier protein domain and the ketosynthase domain plus an adjacent...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yuzawa, Satoshi, Kapur, Shiven, Cane, David E., Khosla, Chaitan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348408/
https://ncbi.nlm.nih.gov/pubmed/22509729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300399u
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