Systemic Delivery of siRNA-Nanoparticles Targeting RRM2 Suppresses Head and Neck Tumor Growth

Systemic delivery of siRNA to solid tumors remains challenging. In this study, we investigated the systemic delivery of an siRNA-nanoparticle targeting ribonucleotide reductase subunit M2 (RRM2), and evaluated its intratumoral kinetics, efficacy and mechanism of action. Knockdown of RRM2 by an RNAi...

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Hoofdauteurs: Rahman, Mohammad Aminur, Amin, A.R.M. Ruhul, Wang, Xu, Zuckerman, Jonathan E., Choi, Chung Hang J., Zhou, Bingsen, Wang, Dongsheng, Nannapaneni, Sreenivas, Koenig, Lydia, Chen, Zhengjia, Chen, Zhuo (Georgia), Yen, Yun, Davis, Mark E., Shin, Dong M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348392/
https://ncbi.nlm.nih.gov/pubmed/22342644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.01.045
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