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RRM2 Regulates Bcl-2 in Head and Neck and Lung Cancers: A Potential Target for Cancer Therapy

PURPOSE: Ribonucleotide reductase subunit M2 (RRM2) plays an active role in tumor progression. Recently, we reported that depletion of RRM2 by systemic delivery of a nanoparticle carrying RRM2-specific siRNA suppresses head and neck tumor growth. The aim of this study is to clarify the underlying me...

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Detalhes bibliográficos
Main Authors: Rahman, Mohammad Aminur, Amin, A.R.M. Ruhul, Wang, Dongsheng, Koenig, Lydia, Nannapaneni, Sreenivas, Chen, Zhengjia, Wang, Zhibo, Sica, Gabriel, Deng, Xingming, Chen, Zhuo (Georgia), Shin, Dong M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747783/
https://ncbi.nlm.nih.gov/pubmed/23719266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0073
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