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Perturbation of nuclear lamin A causes cell death in chondrocytes

OBJECTIVE: Mutations in LMNA encoding the A-type lamins cause several diseases including those with features of premature aging and skeletal abnormalities. We therefore examined the expression of lamin A in cartilage from humans with osteoarthritis (OA) and studied the effects of its overexpression...

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Detalhes bibliográficos
Main Authors: Attur, Mukundan, Ben-Artzi, Ami, Yang, Qing, Al-Mussawir, Hayf E., Worman, Howard J., Palmer, Glyn, Abramson, Steven B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348367/
https://ncbi.nlm.nih.gov/pubmed/22231515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34360
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