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Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement

Mutations in LMNA, which encodes A-type lamins, result in disparate diseases, known collectively as laminopathies, that affect distinct tissues, including striated muscle and adipose tissue. Lamins provide structural support for the nucleus and sites of attachment for chromatin, and defects in these...

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Detalhes bibliográficos
Main Authors: Folker, Eric S., Östlund, Cecilia, Luxton, G. W. Gant, Worman, Howard J., Gundersen, Gregg G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017140/
https://ncbi.nlm.nih.gov/pubmed/21173262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000824108
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