Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity

Hepatic glucose production (HGP) is crucial for glucose homeostasis, but the underlying mechanisms have not been fully elucidated. Here we show that a calcium-sensing enzyme, CaMKII, is activated in a calcium- and IP3R-dependent manner by cAMP and glucagon in primary HCs and by glucagon and fasting...

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Autori principali: Ozcan, Lale, Wong, Catherine C.L., Li, Gang, Xu, Tao, Pajvani, Utpal, Park, Sung Kyu Robin, Wronska, Anetta, Chen, Bi-Xing, Marks, Andrew R., Fukamizu, Akiyoshi, Backs, Johannes, Singer, Harold A., Yates, John R., Accili, Domenico, Tabas, Ira
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348356/
https://ncbi.nlm.nih.gov/pubmed/22503562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.03.002
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