Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity

Hepatic glucose production (HGP) is crucial for glucose homeostasis, but the underlying mechanisms have not been fully elucidated. Here we show that a calcium-sensing enzyme, CaMKII, is activated in a calcium- and IP3R-dependent manner by cAMP and glucagon in primary HCs and by glucagon and fasting...

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Bibliografiske detaljer
Main Authors: Ozcan, Lale, Wong, Catherine C.L., Li, Gang, Xu, Tao, Pajvani, Utpal, Park, Sung Kyu Robin, Wronska, Anetta, Chen, Bi-Xing, Marks, Andrew R., Fukamizu, Akiyoshi, Backs, Johannes, Singer, Harold A., Yates, John R., Accili, Domenico, Tabas, Ira
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348356/
https://ncbi.nlm.nih.gov/pubmed/22503562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.03.002
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