Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer

Castrate resistant prostate cancer (CRPC) is associated with increased androgen receptor (AR) signaling often brought about by elevated intratumoral androgen biosynthesis and AR amplification. Inhibition of androgen biosynthesis and/or AR antagonism should be efficacious in the treatment of CRPC. AK...

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Bibliografische gegevens
Hoofdauteurs: Chen, Mo, Adeniji, Adegoke O., Twenter, Barry M., Winkler, Jeffrey D., Christianson, David W., Penning, Trevor M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348334/
https://ncbi.nlm.nih.gov/pubmed/22507964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.03.085
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