Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease

BACKGOUND: No disease modifying treatment currently exists for Huntington's disease (HD), a fatal neurodegenerative disorder characterized by the formation of amyloid-like aggregates of the mutated huntingtin protein. Curcumin is a naturally occurring polyphenolic compound with Congo red-like a...

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Autors principals: Hickey, Miriam A, Zhu, Chunni, Medvedeva, Vera, Lerner, Renata P, Patassini, Stefano, Franich, Nicholas R, Maiti, Panchanan, Frautschy, Sally A, Zeitlin, Scott, Levine, Michael S, Chesselet, Marie-Françoise
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348060/
https://ncbi.nlm.nih.gov/pubmed/22475209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-12
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