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A unifying model for mTORC1-mediated regulation of mRNA translation
The mTOR Complex 1 (mTORC1) kinase nucleates a pathway that promotes cell growth and proliferation and is the target of rapamycin, a drug with many clinical uses(1). mTORC1 regulates mRNA translation, but the overall translational program is poorly defined and no unifying model exists to explain how...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3347774/ https://ncbi.nlm.nih.gov/pubmed/22552098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11083 |
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