Insulin Resistance, Ceramide Accumulation, and Endoplasmic Reticulum Stress in Human Chronic Alcohol-Related Liver Disease

Background. Chronic alcohol-related liver disease (ALD) is mediated by insulin resistance, mitochondrial dysfunction, inflammation, oxidative stress, and DNA damage. Recent studies suggest that dysregulated lipid metabolism with accumulation of ceramides, together with ER stress potentiate hepatic i...

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Detalhes bibliográficos
Main Authors: Longato, Lisa, Ripp, Kelsey, Setshedi, Mashiko, Dostalek, Miroslav, Akhlaghi, Fatemeh, Branda, Mark, Wands, Jack R., de la Monte, Suzanne M.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347750/
https://ncbi.nlm.nih.gov/pubmed/22577490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/479348
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