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Insulin Resistance, Ceramide Accumulation, and Endoplasmic Reticulum Stress in Human Chronic Alcohol-Related Liver Disease

Background. Chronic alcohol-related liver disease (ALD) is mediated by insulin resistance, mitochondrial dysfunction, inflammation, oxidative stress, and DNA damage. Recent studies suggest that dysregulated lipid metabolism with accumulation of ceramides, together with ER stress potentiate hepatic...

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Main Authors: Lisa Longato, Kelsey Ripp, Mashiko Setshedi, Miroslav Dostalek, Fatemeh Akhlaghi, Mark Branda, Jack R. Wands, Suzanne M. de la Monte
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Limited 2012-01-01
Serija:Oxidative Medicine and Cellular Longevity
Online dostop:http://dx.doi.org/10.1155/2012/479348
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