Insulin Resistance, Ceramide Accumulation, and Endoplasmic Reticulum Stress in Human Chronic Alcohol-Related Liver Disease

Background. Chronic alcohol-related liver disease (ALD) is mediated by insulin resistance, mitochondrial dysfunction, inflammation, oxidative stress, and DNA damage. Recent studies suggest that dysregulated lipid metabolism with accumulation of ceramides, together with ER stress potentiate hepatic...

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Detalhes bibliográficos
Main Authors: Lisa Longato, Kelsey Ripp, Mashiko Setshedi, Miroslav Dostalek, Fatemeh Akhlaghi, Mark Branda, Jack R. Wands, Suzanne M. de la Monte
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Limited 2012-01-01
Colecção:Oxidative Medicine and Cellular Longevity
Acesso em linha:http://dx.doi.org/10.1155/2012/479348
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