Timing of Toll-Like Receptor 9 Agonist Administration in Pneumococcal Vaccination Impacts Both Humoral and Cellular Immune Responses as Well as Nasopharyngeal Colonization in Mice

Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs, CpG ODN, are Toll-like receptor 9 agonists (TLR9a), which have been used as adjuvants in pneumococcal vaccines to improve antibody responses in immunodeficient patients. Here, we examined whether the coadministration of TLR9a...

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Detalhes bibliográficos
Main Authors: Jensen, Katrine M., Melchjorsen, Jesper, Dagnaes-Hansen, Frederik, Sørensen, Uffe B. S., Laursen, Rune R., Østergaard, Lars, Søgaard, Ole S., Tolstrup, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347424/
https://ncbi.nlm.nih.gov/pubmed/22371375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00079-12
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