A Novel Toll-Like Receptor 9 Agonist, MGN1703, Enhances HIV-1 Transcription and NK Cell-Mediated Inhibition of HIV-1-Infected Autologous CD4(+) T Cells

Toll-like receptor (TLR) agonists are potent enhancers of innate antiviral immunity and may also reverse HIV-1 latency. Therefore, TLR agonists have a potential role in the context of a “shock-and-kill” approach to eradicate HIV-1. Our extensive preclinical evaluation suggests that a novel TLR9 agon...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Virol
Päätekijät: Offersen, Rasmus, Nissen, Sara Konstantin, Rasmussen, Thomas A., Østergaard, Lars, Denton, Paul W., Søgaard, Ole Schmeltz, Tolstrup, Martin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2016
Aiheet:
Vaccines and Antiviral Agents
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836316/
https://ncbi.nlm.nih.gov/pubmed/26889036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00222-16
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