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Temperature-Sensitive Mutants and Revertants in the Coronavirus Nonstructural Protein 5 Protease (3CLpro) Define Residues Involved in Long-Distance Communication and Regulation of Protease Activity

Positive-strand RNA virus genomes are translated into polyproteins that are processed by viral proteases to yield functional intermediate and mature proteins. Coronaviruses (CoVs) carry genes that encode an nsp5 protease (also known as 3CLpro or Mpro) responsible for 11 maturation cleavages. The nsp...

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Bibliografski detalji
Glavni autori: Stobart, Christopher C., Lee, Alice S., Lu, Xiaotao, Denison, Mark R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347385/
https://ncbi.nlm.nih.gov/pubmed/22345451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06754-11
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