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Effect of rapamycin on immunity induced by vector-mediated dystrophin expression in mdx skeletal muscle

Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene. Therapeutic gene replacement of a dystrophin cDNA into dystrophic muscle can provide functional dystrophin protein to the tissue. However, vector-mediated gene transfer is limited by anti-vector and anti-transgene host...

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Main Authors: Eghtesad, Saman, Jhunjhunwala, Siddharth, Little, Steven R., Clemens, Paula R.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347316/
https://ncbi.nlm.nih.gov/pubmed/22570764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00399
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