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Influenza Virus H1N1pdm09 Infections in the Young and Old: Evidence of Greater Antibody Diversity and Affinity for the Hemagglutinin Globular Head Domain (HA1 Domain) in the Elderly than in Young Adults and Children

The H1N1 2009 influenza virus (H1N1pdm09) pandemic had several unexpected features, including low morbidity and mortality in older populations. We performed in-depth evaluation of antibody responses generated following H1N1pdm09 infection of naïve ferrets and of 130 humans ranging from the very youn...

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Autors principals: Verma, Nitin, Dimitrova, Milena, Carter, Donald M., Crevar, Corey J., Ross, Ted M., Golding, Hana, Khurana, Surender
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347288/
https://ncbi.nlm.nih.gov/pubmed/22379097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07085-11
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