Oligomeric Recombinant H5 HA1 Vaccine Produced in Bacteria Protects Ferrets from Homologous and Heterologous Wild-Type H5N1 Influenza Challenge and Controls Viral Loads Better than Subunit H5N1 Vaccine by Eliciting High-Affinity Antibodies

Recombinant hemagglutinin from influenza viruses with pandemic potential can be produced rapidly in various cell substrates. In this study, we compared the functionality and immunogenicity of bacterially produced oligomeric or monomeric HA1 proteins from H5N1 (A/Vietnam/1203/04) with those of the eg...

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Detalhes bibliográficos
Main Authors: Verma, Swati, Dimitrova, Milena, Munjal, Ashok, Fontana, Juan, Crevar, Corey J., Carter, Donald M., Ross, Ted M., Khurana, Surender, Golding, Hana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486503/
https://ncbi.nlm.nih.gov/pubmed/22951833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01596-12
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