Recombinant Influenza A Viruses with Enhanced Levels of PB1 and PA Viral Protein Expression

Influenza A viruses containing the promoter mutations G3A/C8U in a given segment express increased levels of the corresponding viral protein during infection due to increased levels of mRNA or cRNA species. The replication of these recombinant viruses is attenuated, and they have an enhanced sheddin...

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Hlavní autoři: Belicha-Villanueva, Alan, Rodriguez-Madoz, Juan R., Maamary, Jad, Baum, Alina, Bernal-Rubio, Dabeiba, Minguito de la Escalera, Maria, Fernandez-Sesma, Ana, García-Sastre, Adolfo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Genome Replication and Regulation of Viral Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347261/
https://ncbi.nlm.nih.gov/pubmed/22398284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06384-11
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