Recombinant Influenza A Viruses with Enhanced Levels of PB1 and PA Viral Protein Expression

Influenza A viruses containing the promoter mutations G3A/C8U in a given segment express increased levels of the corresponding viral protein during infection due to increased levels of mRNA or cRNA species. The replication of these recombinant viruses is attenuated, and they have an enhanced sheddin...

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Detalhes bibliográficos
Main Authors: Belicha-Villanueva, Alan, Rodriguez-Madoz, Juan R., Maamary, Jad, Baum, Alina, Bernal-Rubio, Dabeiba, Minguito de la Escalera, Maria, Fernandez-Sesma, Ana, García-Sastre, Adolfo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347261/
https://ncbi.nlm.nih.gov/pubmed/22398284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06384-11
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