Activity of Dasatinib Against L576P KIT Mutant Melanoma: Molecular, Cellular and Clinical Correlates

Point mutations in the KIT receptor tyrosine kinase gene have recently been identified in mucosal, acral lentiginous, and chronically sun-damaged melanomas. We have identified the first human melanoma cell line with an endogenous L576P mutation, the most common KIT mutation in melanoma (∼30-40%). In...

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Autori principali: Woodman, Scott E., Trent, Jonathan C., Stemke-Hale, Katherine, Lazar, Alexander J., Pricl, Sabrina, Pavan, Giovanni M., Fermeglia, Maurizio, Gopal, Y.N. Vashisht, Yang, Dan, Podoloff, Donald A., Ivan, Doina, Kim, Kevin B., Papadopoulos, Nicholas, Hwu, Patrick, Mills, Gordon B., Davies, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346953/
https://ncbi.nlm.nih.gov/pubmed/19671763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0459
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