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Through the open door: Preferential binding of dasatinib to the active form of BCR‐ABL unveiled by in silico experiments

Dasatinib is a second‐generation BCR‐ABL inhibitor approved for the treatment of patients with chronic myeloid leukemia, both in the frontline and in the imatinib‐resistant/intolerant settings. The high affinity of dasatinib for the protein is currently assumed to result from its ability to bind bot...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Laurini, Erik, Posocco, Paola, Fermeglia, Maurizio, Gibbons, Don L., Quintás-Cardama, Alfonso, Pricl, Sabrina
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528448/
https://ncbi.nlm.nih.gov/pubmed/23816609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2013.06.001
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