Molecular dynamics reveal BCR-ABL1 polymutants as a unique mechanism of resistance to PAN-BCR-ABL1 kinase inhibitor therapy

The acquisition of mutations within the BCR-ABL1 kinase domain is frequently associated with tyrosine kinase inhibitor (TKI) failure in chronic myeloid leukemia. Sensitive sequencing techniques have revealed a high prevalence of compound BCR-ABL1 mutations (polymutants) in patients failing TKI thera...

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Detalhes bibliográficos
Principais autores: Gibbons, Don L., Pricl, Sabrina, Posocco, Paola, Laurini, Erik, Fermeglia, Maurizio, Sun, Hanshi, Talpaz, Moshe, Donato, Nicholas, Quintás-Cardama, Alfonso
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948238/
https://ncbi.nlm.nih.gov/pubmed/24550512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321173111
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