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Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment
Neutrophil migration is vital for immunity and precedes effector functions such as pathogen killing. Here, we report that this process is regulated by the Rab27a GTPase, a protein known to control granule exocytosis. Rab27a-deficient (Rab27a KO) neutrophils exhibit migration defects in vitro and in...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Company of Biologists
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3346826/ https://ncbi.nlm.nih.gov/pubmed/22375060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.100438 |
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