3,5-Bis(benzylidene)-4-oxo-1-phosphonopiperidines and Related Diethyl Esters: Potent Cytotoxins with Multi-Drug-Resistance Reverting Properties

A series of 3,5-bis(benzylidene)-4-piperidones 3 were converted into the corresponding 3,5-bis(benzylidene)-1-phosphono-4-piperidones 5 via diethyl esters 4. The analogues in series 4 and 5 displayed marked growth inhibitory properties toward human Molt 4/C8 and CEM T-lymphocytes as well as murine l...

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Detalhes bibliográficos
Main Authors: Das, Swagatika, Das, Umashankar, Selvakumar, Ponniah, Sharma, Rajendra K., Balzarini, Jan, De Clercq, Erik, Molnár, Joseph, Serly, Julianna, Baráth, Zoltán, Schatte, Gabriele, Bandy, Brian, Gorecki, Dennis K. J., Dimmock, Jonathan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346747/
https://ncbi.nlm.nih.gov/pubmed/19802855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200900288
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