Acyclovir Achieves a Lower Concentration in African HIV-Seronegative, Herpes Simplex Virus 2-Seropositive Women than in Non-African Populations

Acyclovir pharmacokinetics was evaluated in 68 HIV-seronegative, herpes simplex virus 2 (HSV-2)-seropositive African women, who received a single oral 400-mg dose of acyclovir, with plasma acyclovir concentrations measured over 8 h. Geometric mean peak concentration and area under the concentration-...

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Detalhes bibliográficos
Main Authors: Lu, Yanhui, Celum, Connie, Wald, Anna, Baeten, Jared M., Cowan, Frances, Delany-Moretlwe, Sinead, Reid, Stewart E., Hughes, James P., Wilcox, Ellen, Corey, Lawrence, Hendrix, Craig W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346629/
https://ncbi.nlm.nih.gov/pubmed/22330926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06160-11
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