Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial

BACKGROUND: Across many observational studies, herpes simplex virus type 2 (HSV-2) infection is associated with two-fold to three-fold increased risk for HIV-1 infection. We investigated whether HSV-2 suppression with aciclovir would reduce the risk of HIV-1 acquisition. METHODS: We undertook a doub...

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Autors principals: Celum, Connie, Wald, Anna, Hughes, James, Sanchez, Jorge, Reid, Stewart, Delany-Moretlwe, Sinead, Cowan, Frances, Casapia, Martin, Ortiz, Abner, Fuchs, Jonathan, Buchbinder, Susan, Koblin, Beryl, Zwerski, Sheryl, Rose, Scott, Wang, Jing, Corey, Lawrence
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650104/
https://ncbi.nlm.nih.gov/pubmed/18572080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(08)60920-4
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