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Intramolecular Regulation of the Sequence-Specific mRNA Interferase Activity of MazF Fused to a MazE Fragment with a Linker Cleavable by Specific Proteases

The genomes of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) consist of single-stranded RNA encoding polyproteins, which are processed to individual functional proteins by virus-encoded specific proteases. These proteases have been used as targets for drug development. Here...

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Main Authors: Park, Jung-Ho, Yamaguchi, Yoshihiro, Inouye, Masayori
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346410/
https://ncbi.nlm.nih.gov/pubmed/22447587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00364-12
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