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Structural Basis of mRNA Recognition and Cleavage by Toxin MazF and Its Regulation by Antitoxin MazE in Bacillus subtilis

MazF is an mRNA interferase, which, upon activation during stress conditions, cleaves mRNAs in a sequence-specific manner, resulting in cellular growth arrest. During normal growth conditions, the MazF toxin is inactivated through binding to its cognate antitoxin, MazE. How MazF specifically recogni...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Simanshu, Dhirendra K., Yamaguchi, Yoshihiro, Park, Jung-Ho, Inouye, Masayori, Patel, Dinshaw J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691852/
https://ncbi.nlm.nih.gov/pubmed/24120662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.09.006
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