Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a TNF dependent mechanism

Matrix metalloproteinases (MMPs) have been implicated in the modulation of synaptic plasticity, glial activation and long-term potentiation in the CNS. Here we demonstrate for the first time a mechanism for the regulation of nociceptive processing by spinal MMP-3 during peripheral inflammation. We f...

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Bibliographische Detailangaben
Hauptverfasser: Christianson, Christina A., Fitzsimmons, Bethany L., Shim, Jae-Hang, Agrawal, Arpita, Cohen, Seth M., Hua, Xiao-Ying, Yaksh, Tony L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346277/
https://ncbi.nlm.nih.gov/pubmed/22056600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2011.10.019
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