The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically induced Ca(2+) overload

BACKGROUND AND PURPOSE: Reduced cardiac contractility has been associated with disrupted myocardial Ca(2+) signalling. The 1,4 benzothiazepine K201 (JTV-519) acts on several Ca(2+) handling proteins and improves cardiac contractility in vivo in a variety of animal models of myocardial dysfunction. H...

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Bibliografiske detaljer
Main Authors: Kelly, A, Elliott, EB, Matsuda, R, Kaneko, N, Smith, GL, Loughrey, CM
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2012
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346243/
https://ncbi.nlm.nih.gov/pubmed/21658026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01531.x
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