Osteopontin Plays a Critical Role in Interstitial Fibrosis but Not Glomerular Sclerosis in Diabetic Nephropathy

BACKGROUND/AIMS: Osteopontin (OPN) has been implicated in the pathology of several renal conditions. The aim of this study was to clarify the roles of OPN in diabetic nephropathy. METHODS: Diabetes mellitus (DM) was induced in wild-type (WT) and OPN knockout (KO) mice by injecting streptozotocin. Th...

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Main Authors: Nagao, Tomoaki, Okura, Takafumi, Irita, Jun, Jotoku, Masanori, Enomoto, Daijiro, Desilva, Veena Rasika, Miyoshi, Ken-ichi, Kurata, Mie, Matsui, Yutaka, Uede, Toshimitsu, Higaki, Jitsuo
Format: Artigo
Jezik:Inglês
Izdano: S. Karger AG 2012
Teme:
Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346163/
https://ncbi.nlm.nih.gov/pubmed/22619671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000337330
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