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Protein-tyrosine Phosphatase 1B (PTP1B) Deficiency Confers Resistance to Transforming Growth Factor-β (TGF-β)-induced Suppressor Effects in Hepatocytes

Transforming growth factor-β (TGF-β) plays a dual role in hepatocytes, mediating both tumor suppressor and promoter effects. The suppressor effects of the cytokine can be negatively regulated by activation of survival signals, mostly dependent on tyrosine kinase activity. The aim of our work was to...

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Detalhes bibliográficos
Main Authors: Ortiz, Conrad, Caja, Laia, Bertran, Esther, Gonzalez-Rodriguez, Águeda, Valverde, Ángela M., Fabregat, Isabel, Sancho, Patricia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346142/
https://ncbi.nlm.nih.gov/pubmed/22427664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.303958
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