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UU/UA Dinucleotide Frequency Reduction in Coding Regions Results in Increased mRNA Stability and Protein Expression
UU and UA dinucleotides are rare in mammalian genes and may offer natural selection against endoribonuclease-mediated mRNA decay. This study hypothesized that reducing UU and UA (UW) dinucleotides in the mRNA-coding sequence, including the codons and the dicodon boundaries, may promote resistance to...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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Nature Publishing Group
2012
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3345983/ https://ncbi.nlm.nih.gov/pubmed/22434136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.29 |
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