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Fidelity of replication of the leading and the lagging DNA strands opposite N-methyl-N-nitrosourea-induced DNA damage in human cells.

Semi-conservative replication of double-stranded DNA in eukaryotic cells is an asymmetric process involving leading and lagging strand synthesis and different DNA polymerases. We report a study to analyze the effect of these asymmetries when the replication machinery encounters alkylation-induced DN...

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Main Authors: Basic-Zaninovic, T, Palombo, F, Bignami, M, Dogliotti, E
Formato: Artigo
Idioma:Inglês
Publicado: 1992
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC334569/
https://ncbi.nlm.nih.gov/pubmed/1336179
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