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Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking

Palmitoylation, a key regulatory mechanism controlling protein targeting, is catalyzed by DHHC-family palmitoyl acyltransferases (PATs). Impaired PAT activity is linked to several neurodevelopmental and neuropsychiatric disorders, suggesting critical roles for palmitoylation in neuronal function. Ho...

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Detalhes bibliográficos
Main Authors: Thomas, Gareth M., Hayashi, Takashi, Chen, Chih-Ming, Chiu, Shu-Ling, Huganir, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345505/
https://ncbi.nlm.nih.gov/pubmed/22325201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.11.021
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