DHHC8-Dependent PICK1 Palmitoylation is Required for Induction of Cerebellar Long-Term Synaptic Depression

The palmitoyl acyltransferase (PAT) DHHC8 is implicated in synaptic regulation but few DHHC8 substrates are known. Here we report that DHHC8 binds and palmitoylates the PDZ domain-containing protein PICK1 at a cysteine residue that is essential for long-term synaptic depression (LTD) in cultured mou...

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Detalhes bibliográficos
Main Authors: Thomas, Gareth M., Hayashi, Takashi, Huganir, Richard L., Linden, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782620/
https://ncbi.nlm.nih.gov/pubmed/24068808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1283-13.2013
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