Inhibition of hepatic Sulf2 in vivo: a novel strategy to correct diabetic dyslipidemia

BACKGROUND: Type 2 diabetes mellitus (T2DM) impairs hepatic clearance of atherogenic postprandial triglyceride-rich lipoproteins (TRL). We recently reported that livers from T2DM db/db mice markedly overexpress glucosamine-6-O-endosulfatase-2 (SULF2), an enzyme that removes 6-O sulfate groups from h...

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Hlavní autoři: Hassing, H.C., Mooij, H., Guo, S., Monia, B.P., Chen, Keyang, Kulik, W., Dallinga-Thie, G.M., Nieuwdorp, M., Stroes, E.S.G., Williams, K.J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345297/
https://ncbi.nlm.nih.gov/pubmed/22234891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.25580
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