A phosphorothioate at the 3' splice-site inhibits the second splicing step in a group I intron.
RNA polymerases can synthesize RNA containing phosphorothioate linkages in which a sulfur replaces one of the nonbridging oxygens. Only the Rp isomer is generated during transcription. A Rp phosphorothioate at the 5' splice-site of the Tetrahymena group I intron does not inhibit splicing (McSwiggen,...
Uloženo v:
| Vydáno v: | Nucleic Acids Res |
|---|---|
| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
1992
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| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC334520/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1282238/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.23.6303 |
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