Inhibition of Recombinant Human Carboxylesterase 1 and 2 and Monoacylglycerol Lipase by Chlorpyrifos Oxon, Paraoxon and Methyl Paraoxon

Oxons are the bioactivated metabolites of organophosphorus insecticides formed via cytochrome P450 monooxygenase-catalyzed desulfuration of the parent compound. Oxons react covalently with the active site serine residue of serine hydrolases, thereby inactivating the enzyme. A number of serine hydrol...

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Bibliografiske detaljer
Main Authors: Crow, J. Allen, Bittles, Victoria, Herring, Katye L., Borazjani, Abdolsamad, Potter, Philip M., Ross, Matthew K.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345137/
https://ncbi.nlm.nih.gov/pubmed/22100607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2011.10.017
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