Assessment of Colorectal Cancer Molecular Features along Bowel Subsites Challenges the Conception of Distinct Dichotomy of Proximal vs. Distal Colorectum

OBJECTIVE: Colorectal cancer is typically classified into proximal colon, distal colon, and rectal cancer. Tumor genetic and epigenetic features differ by tumor location. Considering a possible role of bowel contents (including microbiome) in carcinogenesis, we hypothesized that tumor molecular feat...

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Autori principali: Yamauchi, Mai, Morikawa, Teppei, Kuchiba, Aya, Imamura, Yu, Qian, Zhi Rong, Nishihara, Reiko, Liao, Xiaoyun, Waldron, Levi, Hoshida, Yujin, Huttenhower, Curtis, Chan, Andrew T., Giovannucci, Edward, Fuchs, Charles S., Ogino, Shuji
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345105/
https://ncbi.nlm.nih.gov/pubmed/22427238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2011-300865
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