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Screening a library of 1,600 adamantyl ureas for anti-Mycobacterium tuberculosis activity in vitro and for better physical chemical properties for bioavailability

Adamantyl ureas were previously identified as a group of compounds active against Mycobacterium tuberculosis in culture with minimum inhibitor concentrations (MICs) below 0.1 μg/ml. These compounds have been shown to target MmpL3, a protein involved in secretion of trehalose mono-mycolate. They also...

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Detaylı Bibliyografya
Asıl Yazarlar: Scherman, Michael S., North, Elton J., Jones, Victoria, Hess, Tammara N., Grzegorzewicz, Anna E., Kasagami, Takeo, Kim, In-Hae, Merzlikin, Oleg, Lenaerts, Anne J., Lee, Richard E., Jackson, Mary, Morisseau, Christophe, McNeil, Michael R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3345085/
https://ncbi.nlm.nih.gov/pubmed/22522007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.03.058
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