Cavities determine the pressure unfolding of proteins

It has been known for nearly 100 years that pressure unfolds proteins, yet the physical basis of this effect is not understood. Unfolding by pressure implies that the molar volume of the unfolded state of a protein is smaller than that of the folded state. This decrease in volume has been proposed t...

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Bibliografiske detaljer
Main Authors: Roche, Julien, Caro, Jose A., Norberto, Douglas R., Barthe, Philippe, Roumestand, Christian, Schlessman, Jamie L., Garcia, Angel E., García-Moreno E., Bertrand, Royer, Catherine A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344970/
https://ncbi.nlm.nih.gov/pubmed/22496593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200915109
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