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Evidence of a large-scale mechanosensing mechanism for cellular adaptation to substrate stiffness

Cell migration plays a major role in many fundamental biological processes, such as morphogenesis, tumor metastasis, and wound healing. As they anchor and pull on their surroundings, adhering cells actively probe the stiffness of their environment. Current understanding is that traction forces exert...

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Autors principals: Trichet, Léa, Le Digabel, Jimmy, Hawkins, Rhoda J., Vedula, Sri Ram Krishna, Gupta, Mukund, Ribrault, Claire, Hersen, Pascal, Voituriez, Raphaël, Ladoux, Benoît
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344951/
https://ncbi.nlm.nih.gov/pubmed/22509005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117810109
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