Interference with Oligomerization and Glycosaminoglycan Binding of the Chemokine CCL5 Improves Experimental Liver Injury

BACKGROUND: The chemokine CCL5 is involved in the recruitment of immune cells and a subsequent activation of hepatic stellate cells (HSC) after liver injury. We here investigate whether inhibition of CCL5 oligomerization and glycosaminoglycan binding by a mutated CCL5 protein ((44)AANA(47)-CCL5) has...

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Hauptverfasser: Nellen, Andreas, Heinrichs, Daniel, Berres, Marie-Luise, Sahin, Hacer, Schmitz, Petra, Proudfoot, Amanda E., Trautwein, Christian, Wasmuth, Hermann E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344902/
https://ncbi.nlm.nih.gov/pubmed/22574195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036614
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