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Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation
Mcm10 is essential for chromosome replication in eukaryotic cells and was previously thought to link the Mcm2-7 DNA helicase at replication forks to DNA polymerase alpha. Here, we show that yeast Mcm10 interacts preferentially with the fraction of the Mcm2-7 helicase that is loaded in an inactive fo...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3343467/ https://ncbi.nlm.nih.gov/pubmed/22433841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.69 |
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